Recent Studies Show That Carpal Tunnel Syndrome Increases Rate of Amyloidosis 12-Fold

Carpal Tunnel Syndrome Studies

A recent study that has been published in the Journal of the American College of Cardiology shows that there might be a connection between carpal tunnel syndrome and amyloidosis. Patients who had surgery due to carpal tunnel syndrome are having a higher risk of heart failure and amyloidosis. 

Combining the recent studies with earlier ones shows that carpal tunnel syndrome might be an early marker for the adverse cardiovascular outcome. Furthermore, the study mentions the development of WTTA (wild-type transthyretin amyloidosis). 

During the research, the scientists analyzed data from over 53,000 patients that underwent surgery because of the carpal tunnel between 1996 and 2012. The average age of the patients was 54, and almost 70% were women. 

The main interest of the research was heart failure hospitalization as well as both outpatient and inpatient diagnosis of amyloidosis. The secondary interest was atrial fibrillation, atrioventricular block, and any kind of implantation like a pacemaker or intracardiac defibrillator implant. Each of the patients was followed up until the end of study, death, an outcome, or emigration depending on which came first. 

The study showed that patients that had carpal tunnel surgery also had an increased risk of potential amyloidosis diagnosis after that. Furthermore, these patients also had a higher frequency of heart failure after surgery compared with the controls. Finally, they had an increased risk of an adverse outcome that could include atrioventricular block.

While carpal tunnel syndrome is not directly related to amyloidosis, the occurrence of CTS might be an early red flag that might help doctors detect amyloidosis earlier. In select patients, CTS might be a warning sign that can help monitor and track amyloid development years before the amyloidosis is triggered.

The study was conducted by The Heart Center at the University Hospital of Copenhagen Rigshospitalet in Denmark.